The Systems Biology Group in this project aims at understanding and
designing of biological systems and creates a new paradigm in biology,
Systems Biology. As model organisms, we focus on Drosophila melanogaster,
Caenorhabditis elegans, Saccharomyces cerevisiae, and
Escherichia coli. By investigating the genetic, cellular and
metabolic mechanisms together with their computer simulations, we will
develop novel instrumentation systems and analysis theory. Advanced
imaging technologies, reverse engineering methods from experimental
data, and other related technologies will be developed.
What is Systems Biology?
Systems Biology is a new field in biology that aims at system-level
understanding of biological systems, and to understand "Biological System
as System." System-level understanding essentially requires that we
need to accomplish followings:
- Understanding of system structures
- Understanding of behaviors of the system
- Understanding how to control the system
- Understanding how to design the system
This requires research in broad range of areas such as molecular biology,
computer science, control theory and engineering, technologies for quantitative
measurements, micro manipulations, and other technologies. Details shall
be refered to:
- Perspectives on Systems Biology, New Generation Computing,
Vol. 18, 199-216 (2000)
- Perspectives on Systems Biology, Jounral of Japanese Society for
Artificial Intelligence, Jan, 2000 (in Japanese)
- Introduction to Systems Biology, Cell Technology Magazine, Jan,
Feb, March, ... 2000 (a series article in Japanese)
- Systems Biology, Invited talk at National Institute of Genetics,
1997, California Institute of Technology, March, 1998 and Hamamatsu
Photonics Symposium, Janunary, 1999. (Slides to be up-loaded soon)
[International
Conferences on Systems Biology]
- The 5th International
Conference on Systems Biology (ICSB 2004)
2004/10/9-13 Heidelberg, Germany
- ICSB-2003
2003/11/5 - 10, St. Louis, MO, USA
- ICSB-2002
2002/12/13 - 15, Karolinska Institutet, Stockholm, Sweden.
- ICSB-2001
2001/Nov, California Institute of Technology.
- The First
International Conference on Systems Biology (ICSB-2000) took
place
2000, November 14-16, in Tokyo, Japan.
Tokyo Unit
- Computer simulations of development in Drosophila melanogaster
- Architechure for simulating genetic mechanisms and Development of
Multicellular Organisms
- Advanced imaging systems for systems biology
- Software for reverse engineering genetic and metabolic networks
from experimental data
- Simulations of control mechanisms of metabolic pathways in Saccharomyces
cerevisiae
Caltech Unit
- Design and development of a general-purpose simulation system for
gene regulation and metabolism
- Modeling of cell cycle and computer simulation system
- Modeling of Escherichia coli and computer simulation
System
- SBML / SBW=System
Biology Workbench
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